Ipamorelin 10mg

€49.99

Technical Specifications

Specification	Detail
Product Name	Ipamorelin
Quantity	10mg per vial
Purity	>97.0% (HPLC verified)
Form	Lyophilized powder, no additives
Appearance	Sterile filtered white powder
Molecular Weight	711.85 Da
CAS Number	170851-70-4
Amino Acid Sequence	Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Solubility	Sterile 18MΩ-cm H₂O at ≥100 µg/ml
Storage (Lyophilized)	Below -18°C; stable at room temperature for 3 weeks; protect from light and moisture
Storage (Reconstituted)	4°C for 2-7 days; below -18°C for long-term with carrier protein
Shelf Life	24 months from manufacture date
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

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Description

Premium Ipamorelin Peptide for Sale | 10mg Lyophilized Powder | ≥97% Purity | 48-Hour Delivery Across EU & UK

Ipamorelin: The First Selective Growth Hormone Secretagogue for Advanced Research

Buy Ipamorelin 10mg Online EU & UK, eupeptidelap.co.uk is proud to present Ipamorelin 10mg, a premium research-grade pentapeptide growth hormone secretagogue manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with Ipamorelin for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in endocrinology, muscle physiology, and metabolic research .

Ipamorelin is a synthetic pentapeptide with the amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂, molecular formula C₃₈H₄₉N₉O₅, and molecular weight of approximately 711.85 Da . Developed as part of a major chemistry programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth hormone-releasing peptide (GHRP)-1 . What distinguishes ipamorelin from earlier GHRPs is its remarkable selectivity profile—it is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH .

In vitro studies demonstrate that ipamorelin releases GH from primary rat pituitary cells with potency and efficacy similar to GHRP-6 (EC₅₀ = 1.3 ± 0.4 nmol/L and Emax = 85 ± 5% vs 2.2 ± 0.3 nmol/L and 100%) . It binds to COS-7 cells expressing GHS-R1a with a Ki of 63.4 nM and induces inositol-1,4,5-triphosphate (IP₃) accumulation in BHK cells expressing GHS-R1a (EC₅₀ = 46.9 nM) . Buy Ipamorelin 10mg Online EU & UK

For researchers seeking to buy peptide online EU for investigations into growth hormone dynamics, muscle health, gastrointestinal motility, or age-related endocrine decline, eupeptidelap.co.uk offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

The Scientific Foundation of Ipamorelin Research

Discovery and Development

Ipamorelin was developed and first described in the scientific literature by Raun and colleagues in a landmark 1998 publication in the European Journal of Endocrinology . As the outcome of a major chemistry programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of GHRP-1, representing a significant advancement in the design of selective growth hormone secretagogues .

Mechanism of Action: Selective GHSR Activation

Ipamorelin exerts its effects through highly selective binding to growth hormone secretagogue receptor 1a (GHS-R1a), the same receptor targeted by the endogenous hormone ghrelin .

GHSR Binding and Signaling: Ipamorelin binds to GHS-R1a with a Ki of 63.4 nM and induces IP₃ accumulation in cells expressing the receptor (EC₅₀ = 46.9 nM), confirming its agonist activity at this receptor . This activation triggers intracellular calcium mobilization and downstream signaling cascades that stimulate GH release from pituitary somatotroph cells.

Selective GH Release: A pharmacological profiling using GHRP and GHRH antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor . In pentobarbital anaesthetised rats, ipamorelin released GH with an ED₅₀ of 80 ± 42 nmol/kg and Emax of 1545 ± 250 ng GH/mL, comparable to GHRP-6 (ED₅₀ = 115 ± 36 nmol/kg and Emax = 1167 ± 120 ng GH/mL) .

Superior Selectivity Profile: The specificity for GH release was studied in swine. While administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation . This lack of effect on ACTH and cortisol plasma levels was evident even at doses more than 200-fold higher than the ED₅₀ for GH release . None of the GH secretagogues tested affected FSH, LH, PRL, or TSH plasma levels .

In Vivo Activity

In conscious swine, ipamorelin released GH with an ED₅₀ of 2.3 ± 0.03 nmol/kg and an Emax of 65 ± 0.2 ng GH/mL plasma, very similar to GHRP-6 (ED₅₀ = 3.9 ± 1.4 nmol/kg and Emax = 74 ± 7 ng GH/mL plasma) . GHRP-2 displayed higher potency but lower efficacy (ED₅₀ = 0.6 nmol/kg and Emax = 56 ± 6 ng GH/mL plasma) .

Ipamorelin (18-450 µg/animal) increases body weight and longitudinal bone growth in rats . It also increases gastric emptying in rat models of postoperative ileus induced by laparotomy and intestinal manipulation when administered at doses of 0.014 or 0.14 µmol/kg .

Key Research Applications

Endocrine and Growth Hormone Dynamics Research

Ipamorelin serves as a sophisticated tool for investigating growth hormone physiology and regulation . Its unique selectivity for GH release without affecting ACTH, cortisol, or other pituitary hormones makes it invaluable for studying isolated GH axis function . Applications include:

Characterizing GH pulsatility and feedback mechanisms
Investigating GHSR-mediated signaling pathways
Studying the interaction between GHRH and GHSR systems

Muscle Health and Sarcopenia Research

Ipamorelin is extensively studied for its effects on muscle tissue and age-related muscle loss . Sarcopenia, the progressive loss of skeletal muscle mass and function with advancing age, affects up to 8% of muscle mass per decade after age 30 . Ipamorelin’s ability to stimulate endogenous GH release promotes protein synthesis and muscle fiber growth through subsequent IGF-1 elevation .

In older adults, GH secretagogues have been shown to influence body composition and muscle-related outcomes. A randomized, double‑blind, placebo‑controlled study in adults age 65–84 investigating the orally active growth hormone secretagogue capromorelin demonstrated significant increases in lean body mass (~1.4 kg vs 0.3 kg with placebo) and improvements in physical performance measures .

Gastrointestinal Motility Research

Ipamorelin has demonstrated significant gastrokinetic efficacy in preclinical models . In rat models of post-operative ileus induced by laparotomy and intestinal manipulation, ipamorelin administered at doses of 0.014 or 0.14 µmol/kg significantly increased gastric emptying . Studies evaluating ipamorelin at doses of 10 or 100 mg/kg orally, and 0.1, 0.25, or 1.0 mg/kg intravenously, confirmed its ability to stimulate gastrointestinal motility .

Bone Growth Research

Ipamorelin increases longitudinal bone growth in rats (18-450 µg/animal), supporting its relevance for research into bone density and skeletal health . By stimulating GH and subsequent IGF-1 production, ipamorelin may influence osteoblast activity and bone formation processes.

Metabolic and Body Composition Research

GH plays a fundamental role in regulating metabolism, and ipamorelin’s selective GH release makes it valuable for metabolic studies . Research applications include:

Investigating lipolysis and fat metabolism
Studying body composition changes
Examining the relationship between GH and metabolic homeostasis

Anti-Aging and Neuroendocrine Research

Age-related decline in GH secretion (somatopause) is associated with reduced cellular repair, bone density loss, and decreased cognitive vitality . Ipamorelin’s ability to restore endogenous GH pulsatility makes it valuable for investigating strategies to mitigate age-related decline and for studying growth hormone dynamics in aging models .

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

eupeptidelap.co.uk sources Ipamorelin 10mg from certified GMP facilities with rigorous quality control protocols:

HPLC Purity Analysis: >97.0% purity verified by reverse-phase high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation via LC-HRMS
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Sterile Manufacturing: Lyophilized with no additives; sterile filtered
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations

Chemical and Product Specifications

Specification	Detail
Product Name	Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH₂)
CAS Number	170851-70-4
Molecular Formula	C₃₈H₄₉N₉O₅
Molecular Weight	~711.85 Da
Amino Acid Sequence	Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Purity	>97.0% (HPLC verified)
Appearance	Sterile filtered white lyophilized powder
Form	Lyophilized powder with no additives
Solubility	Reconstitute in sterile 18MΩ-cm H₂O at not less than 100 µg/ml
Storage (Lyophilized)	Below -18°C, desiccated; stable at room temperature for 3 weeks
Storage (Reconstituted)	4°C for 2-7 days; below -18°C for long-term with carrier protein (0.1% HSA or BSA)
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

Stability and Handling Guidelines

Lyophilized Powder Storage: Store lyophilized ipamorelin powder below -18°C in a dry, dark environment, protected from light and moisture, and kept desiccated . While the peptide is stable at room temperature for up to 3 weeks, refrigeration or freezing is recommended for extended storage.

Reconstitution Protocol :

Allow vial and solvent to reach ambient temperature before opening to prevent condensation
Reconstitute using sterile 18MΩ-cm H₂O at not less than 100 µg/ml, which can then be further diluted to other aqueous solutions
Inject solvent slowly down the inside wall of the vial to minimize foaming
Gently swirl or roll the vial until fully dissolved—do not shake vigorously
Label the vial with the date of reconstitution
Refrigerate immediately at 4°C

Reconstituted Solution Storage: Store reconstituted ipamorelin at 4°C for 2-7 days . For long-term storage, aliquot into single-use portions, add a carrier protein (0.1% HSA or BSA), and store below -18°C. Prevent repeated freeze-thaw cycles.

Protection from Light and Moisture:

Store in original packaging protected from light
Keep vials tightly sealed when not in use
Allow refrigerated vials to reach room temperature before opening to prevent condensation

Key Benefits

Premium Quality Manufacturing: GMP-certified production, >97% HPLC-verified purity with lot-specific COAs
First Selective GHS Agonist: Unique among GHRPs for its selectivity profile similar to GHRH
Superior Hormonal Selectivity: No effect on ACTH, cortisol, FSH, LH, prolactin, or TSH even at >200-fold higher doses
Potent GH Release: EC₅₀ of 1.3 nM in primary rat pituitary cells
Gastrointestinal Research: Increases gastric emptying in post-operative ileus models
Bone Growth Studies: Increases longitudinal bone growth in rats
Muscle Health Research: Supports investigation of age-related sarcopenia and muscle preservation
Endocrine Research: Ideal for studying isolated GH axis function without confounding hormonal effects
Metabolic Research: Valuable tool for investigating GH-mediated metabolic pathways
Well-Characterized Safety Profile: Favorable selectivity profile minimizes off-target hormonal effects
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is Ipamorelin and how does it work?

A: Ipamorelin is a synthetic pentapeptide growth hormone secretagogue and GHS receptor 1a (GHS-R1a) agonist . It stimulates GH release by binding to GHS-R1a receptors on pituitary somatotroph cells, with an EC₅₀ of 1.3 nM in primary rat pituitary cells .

Q: What makes Ipamorelin unique among growth hormone secretagogues?

A: Ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH . Unlike GHRP-6 and GHRP-2, ipamorelin does not stimulate ACTH or cortisol release, even at doses more than 200-fold higher than its ED₅₀ for GH release .

Q: What purity level can I expect when I buy Ipamorelin from eupeptidelap.co.uk?

A: All Ipamorelin 10mg from eupeptidelap.co.uk is tested to >97.0% purity by RP-HPLC . Each batch is individually analyzed, and Certificates of Analysis are provided with every order, ensuring you receive material suitable for rigorous research applications.

Q: What is the molecular weight and sequence of Ipamorelin?

A: Ipamorelin has a molecular weight of approximately 711.85 Da, molecular formula C₃₈H₄₉N₉O₅, and the amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂ .

Q: How should I store Ipamorelin for long-term stability?

A: Store lyophilized ipamorelin powder below -18°C in a dry, dark environment, protected from light and moisture, and kept desiccated . While stable at room temperature for up to 3 weeks, refrigeration or freezing is recommended for extended storage.

Q: What is the recommended reconstitution protocol for Ipamorelin?

A: Reconstitute using sterile 18MΩ-cm H₂O at not less than 100 µg/ml, which can then be further diluted to other aqueous solutions . Inject solvent slowly, gently swirl—do not shake. After reconstitution, store at 4°C for 2-7 days. For long-term storage, add a carrier protein (0.1% HSA or BSA) and store below -18°C.

Q: What research areas commonly use Ipamorelin?

A: Ipamorelin is widely used in endocrine and growth hormone dynamics research, muscle health and sarcopenia studies, gastrointestinal motility research, bone growth studies, metabolic and body composition research, and anti-aging and neuroendocrine research .

Q: Does Ipamorelin affect other pituitary hormones?

A: No. Studies in swine demonstrate that ipamorelin does not affect plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, or thyroid stimulating hormone (TSH) . Importantly, unlike GHRP-6 and GHRP-2, it does not increase ACTH or cortisol levels .

Q: Do you ship Ipamorelin to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship Ipamorelin 10mg to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays. All shipments use protective packaging to maintain compound integrity during transit.

Q: What documentation do you provide with Ipamorelin orders?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data. Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.

Q: Is Ipamorelin legal to purchase for research in the UK and EU?

A: In the EU and UK, peptides are legal to purchase for research purposes when properly labeled and supplied to qualified buyers such as laboratories and research facilities . They cannot be marketed or sold as supplements, cosmetics, or medical treatments without approval from the EMA or MHRA . At eupeptidelap.co.uk, all products are intended for research and laboratory use only.

Q: Do you offer bulk quantities of Ipamorelin for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements for ongoing research programs.

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