NAD+ 1,000mg

NAD+ (Nicotinamide Adenine Dinucleotide) | Analytical Research Grade

Are you seeking a verified, high-purity source for NAD+ for sale online in Europe for laboratory use? Nicotinamide Adenine Dinucleotide is a critical coenzyme found in all living cells, serving as the essential electron carrier in redox reactions. Within the scientific community, it is the primary subject for researchers investigating mitochondrial bioenergetics, DNA repair mechanisms, and the molecular hallmarks of aging.

We provide analytical-grade NAD+ powder, verified via HPLC and LC-HRMS to ensure the $\geq$99% purity required for rigorous in vitro enzymatic assays and metabolic flux analysis.

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Biochemical Profile & Metabolic Pathways

NAD+ is utilized as a sophisticated chemical probe to study the interconnected synthesis and consumption pathways in mammalian cells. Researchers utilize this compound to explore:

• Salvage Pathway Dynamics: Investigating the rate-limiting role of NAMPT in recycling nicotinamide into NMN and subsequently NAD+.

• Sirtuin Activation: Researching the NAD+-dependent deacetylation of proteins by Sirtuins (SIRT1-7), which regulates genomic stability and stress responses.

• Mitochondrial Homeostasis: Studying the TCA cycle and oxidative phosphorylation, where NAD+ acts as the primary acceptor of electrons to form NADH.

• DNA Integrity: Utilizing NAD+ as the mandatory substrate for PARP enzymes, which identify and signal single-strand DNA breaks.

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Primary Research & Forensic Applications

NAD+ Powder is an essential reference material for several advanced scientific domains:

• Aging & Longevity Research: Investigating the age-related decline of systemic NAD+ levels and its correlation with mitochondrial dysfunction and chronic inflammation (inflammaging).

• Neurodegenerative Studies: Exploring the neuroprotective potential of NAD+ in models of Alzheimer’s and Parkinson’s, specifically focusing on the correction of RNA splicing errors via the EVA1C pathway.

• Premature Aging Disorders: Serving as a tool to study Werner syndrome and Cockayne syndrome, where hyperactivation of PARPs leads to critical NAD+ depletion.

• Metabolic Flux Analysis: Utilizing high-purity standards to calibrate LC-MS/MS systems for the quantification of NAD+ pools across distinct subcellular compartments (nucleus vs. mitochondria).

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Technical Specifications

Feature	Details
IUPAC Name	Nicotinamide adenine dinucleotide
CAS Number	53-84-9
Molecular Formula	$C_{21}H_{27}N_{7}O_{14}P_{2}$
Molar Mass	663.43 g/mol
Purity Grade	Analytical Grade ($\geq$99%)
Appearance	White to off-white lyophilized powder
Solubility	$\text{H}_{2}\text{O}$ (50 mg/mL), PBS (10 mg/mL)

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Safety, Regulatory Status, and Procurement

NAD+ is intended strictly for authorized laboratory research and is not for human or veterinary consumption.

• Regulatory Compliance: This compound is available for laboratory use in the UK and EU. Procurement requires adherence to institutional safety guidelines and professional research status.

• Handling & PPE: Due to its biological activity, the use of Personal Protective Equipment (PPE), including nitrile gloves and eye protection, is required. Handle in a controlled environment to maintain sterility.

• Storage & Stability: Store lyophilized powder at -20°C in a manual-defrost freezer. Protect from light and moisture. Once reconstituted, store aliquots at -20°C for up to 1 month to avoid degradation from freeze-thaw cycles.

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Why Source Through Licensed Distribution Channels?

• Verified Analytical Integrity: Every batch is independently tested via HPLC and MS to ensure results meet peer-reviewed publication standards.

• Batch-to-Batch Reproducibility: Rigorous GMP-style quality control ensures consistent results across long-term longitudinal studies.

• Technical Documentation: All orders are accompanied by a batch-specific Certificate of Analysis (COA) and Safety Data Sheet (SDS).

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NAD+ for sale online in Europe

Advance your cellular metabolism and aging investigations with certified NAD+ standards. Contact our specialized technical team today to secure high-purity materials for your facility.