GHK-CU 50mg

€43.99

Technical Specifications

Specification	Detail
Product Name	GHK-Cu (Copper Tripeptide-1)
Quantity	50mg per vial
Purity	≥98% (HPLC verified)
Form	Lyophilized powder
Appearance	Blue to purple lyophilized powder
Molecular Weight	~485.99 g/mol
CAS Number	49557-75-7
Amino Acid Sequence	Gly-His-Lys with Cu²⁺ binding
Stability Constant	log₁₀(K) = 16.44
Storage (Lyophilized)	2-8°C; protect from light and moisture
Storage (Reconstituted)	2-8°C for short-term; -20°C for long-term, aliquot
Shelf Life	24 months from manufacture date
Shipping	Ambient temperature with protective packaging
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

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Description

Premium GHK-Cu (Copper Peptide) for Sale | ≥98% Purity | 50mg Lyophilized Powder | 48-Hour Delivery Across EU & UK

GHK-Cu: The Master Copper-Binding Peptide for Advanced Research

Buy GHK-Cu 50mg Online EU & UK, eupeptidelap.co.uk is proud to present GHK-Cu 50mg, a premium research-grade copper-binding peptide manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with GHK-Cu for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in tissue regeneration, wound healing, and anti-aging mechanisms .

GHK-Cu (glycyl-L-histidyl-L-lysine-copper) is a naturally occurring copper peptide complex first discovered in human plasma by Dr. Loren Pickart in 1973, where it was shown to promote cell growth and tissue repair . The molecule has a strong affinity for copper(II) ions, forming the stable chelated complex GHK-Cu that serves as both a signal peptide and a carrier peptide, supporting extracellular matrix remodelling and being released at sites of inflammation or tissue injury .

Physiologically, plasma concentrations of GHK average about 200 ng/mL at age 20 but decline to approximately 80 ng/mL by age 60, a reduction that correlates with the body’s decreased regenerative capacity over time . GHK-Cu is also naturally present in human saliva and urine, underscoring its fundamental biological importance. Buy GHK-Cu 50mg Online EU & UK

For researchers seeking to buy peptide online EU for investigations into skin regeneration, wound healing, anti-aging mechanisms, or hair growth studies, eupeptidelap.co.uk offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

The Scientific Foundation of GHK-Cu Research

Discovery and Historical Context

The copper tripeptide GHK-Cu was first identified and developed by Dr. Loren Pickart in 1973, marking a key early milestone in regenerative and aesthetic peptide science . However, it was not until the late 1980s that copper peptides began appearing in commercial skincare formulations . Over the decades, its applications have expanded into dermatology and cosmetic science, supported by an increasing body of clinical and biochemical research .

Mechanism of Action

GHK-Cu functions through multiple sophisticated mechanisms that make it one of the most versatile peptides in regenerative research :

Signal and Carrier Peptide Activity: GHK-Cu acts as both a signal peptide that regulates gene expression and a carrier peptide that stabilises and transports copper ions critical for wound healing, enzymatic activation, and tissue regeneration . The copper ion facilitates essential enzymatic reactions such as those catalyzed by lysyl oxidase and superoxide dismutase, which are critical for collagen crosslinking and oxidative stress mitigation .

Gene Expression Regulation: GHK-Cu has been associated with the upregulation of genes involved in tissue repair, anti-inflammatory signaling, and antioxidant defense, and the downregulation of genes linked to fibrosis and oxidative stress . Studies show that GHK-Cu can restore the expression of many genes to a “healthy” profile, essentially resetting them to a younger, healthier state .

Stimulation of Extracellular Matrix Proteins: GHK-Cu is a potent stimulator of collagen, elastin, glycosaminoglycans, and proteoglycans—structural proteins essential for the integrity, firmness, and elasticity of skin and connective tissues . It stimulates fibroblasts to produce glycogen, glycosaminoglycans, and collagen, accelerating skin repair .

Angiogenesis Promotion: GHK-Cu supports the formation of new blood vessels, thus improving skin nourishment and tissue perfusion during healing processes .

Anti-inflammatory and Antioxidant Effects: GHK-Cu exhibits potent anti-inflammatory and antioxidant properties, neutralizing free radicals, reducing inflammatory processes, and protecting cells from oxidative damage .

Immune Response Modulation: The peptide attracts immune cells to damaged skin, enhancing the body’s natural healing responses .

Structural Stability and Purity

The GHK-Cu complex demonstrates exceptional stability, with one of the highest stability constants (log₁₀(K) = 16.44) among copper complexes . This remarkable stability ensures that the peptide maintains its biological activity throughout research applications. X-ray crystallography, NMR, and spectroscopy studies have confirmed that Cu²⁺ binds to the imidazole nitrogen of histidine, the α-amino nitrogen of glycine, and the nitrogen of the peptide bond between glycine and histidine .

Key Research Applications

Skin Regeneration and Anti-Aging Research

GHK-Cu is extensively studied for its dual-action benefits on skin health, supporting both internal tissue repair and external rejuvenation :

Collagen and Elastin Stimulation: GHK-Cu stimulates collagen and glycosaminoglycan synthesis in fibroblasts, promoting skin firmness and elasticity . Studies have shown that GHK-Cu can be considered an effective anti-wrinkle ingredient based on cellular studies .

Anti-Wrinkle Studies: Topical application has been shown to stimulate procollagen synthesis and reduce fine lines and wrinkles . GHK-Cu and its derivatives are widely used in anti-wrinkle products available on the cosmetic market .

Skin Density and Thickness: Research demonstrates that GHK-Cu improves skin density, thickness, elasticity, and moisture, producing smoother, more youthful-appearing skin .

Wound Healing Research

GHK-Cu has demonstrated significant therapeutic potential in wound healing research :

Phase 2 Clinical Trial: A Phase 2 randomized, double-blind, vehicle-controlled, split-wound study is currently underway to evaluate topical GHK-Cu gel (0.1% w/w) for accelerating re-epithelialization of standardized acute skin wounds in healthy adults . The primary outcome is time to complete re-epithelialization, with secondary outcomes including wound area reduction, local symptoms, infection rate, and scar quality at 12 weeks .

Bioactive Wound Healing: Hydrogels incorporating GHK peptide nanofibers have demonstrated enhanced wound healing capabilities, promoting cell proliferation, migration, and collagen remodeling—critical factors in tissue regeneration . The complexation of Cu²⁺ into GHK nanofibers resulted in superior wound healing capabilities compared with non-lipidated GHK peptide, with efficacy comparable to growth factors .

Angiogenesis Enhancement: Nanostructured Cu-GHK improves angiogenesis through vascular endothelial growth factor (VEGF) activation, exerting synergistic therapeutic effects .

Hair Growth Research

GHK-Cu has garnered significant interest for potential use in alopecia research :

Follicle Stimulation: GHK-Cu promotes the growth of hair follicle cells, reduces their apoptosis, stimulates the generation of blood vessels around hair follicles, provides sufficient nutrition for hair follicles, and then enlarges hair follicles, accelerating the production of thicker hair .

DHT Inhibition: Copper ions have an inhibitory effect on type I 5-α reductase, which can reach 90% . The use of GHK-Cu can introduce copper ions into the skin, thereby reducing the secretion of androgens and relieving its inhibitory effect on hair growth .

Anti-Inflammatory and Antioxidant Research

GHK-Cu exerts meaningful anti-inflammatory and antioxidant actions :

Cytokine Modulation: GHK-Cu reduces pro-inflammatory cytokines while increasing anti-inflammatory mediators .

Oxidative Stress Reduction: The peptide helps buffer the intracellular environment against oxidative damage—a contributor to both aging and tissue degeneration . Studies have shown that GHK-Cu can mitigate oxidative stress and neuroinflammation .

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

eupeptidelap.co.uk sources GHK-Cu 50mg from certified GMP facilities with rigorous quality control protocols :

HPLC Purity Analysis: ≥98% purity verified by high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation via LC-HRMS
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Third-Party Lab Testing: Independent verification of purity and potency
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations

Chemical and Product Specifications

Specification	Detail
Product Name	GHK-Cu (Copper Tripeptide-1, Glycyl-L-Histidyl-L-Lysine Copper)
CAS Number	49557-75-7
Molecular Formula	C₁₄H₂₂N₆O₄Cu·C₄H₄O₂ (acetate salt)
Molecular Weight	~485.99 g/mol
Purity	≥98% (HPLC verified)
Appearance	Blue to purple lyophilized powder
Form	Lyophilized powder
Solubility	Soluble in water, PBS, and aqueous buffers
Stability Constant	log₁₀(K) = 16.44
Storage (Lyophilized)	2-8°C; protect from light and moisture
Storage (Reconstituted)	2-8°C for short-term; aliquot and freeze at -20°C for longer storage
Shelf Life	24 months from date of manufacture
Shipping	Ambient temperature with protective packaging
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

Stability and Handling Guidelines

Lyophilized Powder Storage: Store lyophilized GHK-Cu powder at 2-8°C in a dry, dark environment, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months from the date of manufacture.

Reconstitution Protocol:

Allow vial and solvent to reach ambient temperature before opening to prevent condensation
Reconstitute using sterile 18MΩ-cm H₂O at not less than 100 μg/ml, which can then be further diluted to other aqueous solutions
Inject solvent slowly down the inside wall of the vial to minimize foaming
Gently swirl or roll the vial until fully dissolved—do not shake vigorously
Label the vial with the date of reconstitution
Refrigerate immediately at 2-8°C

Reconstituted Solution Storage: Store reconstituted GHK-Cu at 2-8°C for short-term use. For longer-term storage, aliquot into single-use portions and store at -20°C. Avoid repeated freeze-thaw cycles as this can degrade the peptide.

Protection from Light and Moisture:

Store in original packaging protected from light
Keep vials tightly sealed when not in use
Allow refrigerated vials to reach room temperature before opening to prevent condensation

Important Handling Note: GHK-Cu solutions and powders appear blue because of the copper(II) ion complexed with the peptide. This characteristic blue color is a normal property of the compound.

Key Benefits

Premium Quality Manufacturing: GMP-certified production, ≥98% HPLC-verified purity
Well-Characterized Mechanism: Extensively studied copper peptide with defined structural properties
Exceptional Stability: One of the highest stability constants among copper complexes (log₁₀(K) = 16.44)
Gene Expression Regulation: Modulates expression of genes involved in tissue repair and inflammation
Collagen Synthesis Stimulation: Promotes collagen and glycosaminoglycan production in fibroblasts
Angiogenesis Promotion: Supports new blood vessel formation through VEGF activation
Wound Healing Research: Currently in Phase 2 clinical trials for accelerating skin wound healing
Anti-Inflammatory Effects: Reduces inflammatory processes and cytokine production
Antioxidant Protection: Neutralizes free radicals and protects against oxidative stress
Hair Growth Research: Stimulates hair follicle cells and inhibits DHT formation
Skin Rejuvenation Studies: Reduces fine lines and improves skin density and elasticity
Immune Modulation: Attracts immune cells to enhance natural healing responses
Clinical Validation: Supported by ongoing clinical trials and extensive preclinical research
High Purity: ≥98% purity ensures reliable, reproducible research results
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is GHK-Cu and where does it come from?

A: GHK-Cu (glycyl-L-histidyl-L-lysine-copper) is a naturally occurring copper-binding tripeptide first discovered in human plasma in 1973 . It is composed of the three amino acids glycine, histidine, and lysine complexed with a copper ion, and plays essential roles in tissue regeneration, wound healing, and anti-aging processes . It is also naturally present in human saliva and urine .

Q: Why does GHK-Cu appear blue?

A: GHK-Cu solutions and powders appear blue because of the copper(II) ion complexed with the peptide . This characteristic blue color is a normal property of the compound and confirms the presence of the copper complex.

Q: What purity level can I expect when I buy GHK-Cu from eupeptidelap.co.uk?

A: All GHK-Cu 50mg from eupeptidelap.co.uk is tested to ≥98% purity by HPLC . Each batch is individually analyzed, and Certificates of Analysis are provided with every order, ensuring you receive material suitable for rigorous research applications.

Q: What is the stability of the GHK-Cu complex?

A: GHK-Cu demonstrates exceptional stability with one of the highest stability constants among copper complexes (log₁₀(K) = 16.44) . This remarkable stability ensures that the peptide maintains its biological activity throughout research applications.

Q: How should I store GHK-Cu for long-term stability?

A: Store lyophilized GHK-Cu powder at 2-8°C, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months from the date of manufacture. After reconstitution, store at 2-8°C for short-term use. For longer-term storage, aliquot into single-use portions and store at -20°C. Avoid repeated freeze-thaw cycles.

Q: What is the recommended reconstitution protocol for GHK-Cu?

A: Reconstitute using sterile 18MΩ-cm H₂O at not less than 100 μg/ml, which can then be further diluted to other aqueous solutions. Inject solvent slowly down the inside wall of the vial to minimize foaming, gently swirl—do not shake. After reconstitution, store at 4°C for short-term use. For long-term storage, aliquot into single-use portions and store at -20°C.

Q: What research areas commonly use GHK-Cu?

A: GHK-Cu is widely used in skin regeneration and anti-aging research , wound healing studies , hair growth research , anti-inflammatory and antioxidant research , and gene expression regulation studies .

Q: Has GHK-Cu been studied in clinical trials?

A: Yes. A Phase 2 clinical trial is currently underway evaluating topical GHK-Cu gel (0.1% w/w) for accelerating acute skin wound healing . The study aims to determine whether GHK-Cu gel reduces time to complete re-epithelialization compared to vehicle control .

Q: Do you ship GHK-Cu to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship GHK-Cu 50mg to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays. All shipments use protective packaging to maintain compound integrity during transit.

Q: What documentation do you provide with GHK-Cu orders?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data. Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.

Q: Does GHK-Cu have applications in hair growth research?

A: Yes. GHK-Cu stimulates hair follicle growth by promoting angiogenesis, reducing apoptosis in dermal papilla cells, and inhibiting DHT formation through copper’s inhibitory effect on type I 5-α reductase .

Q: What is the molecular weight and CAS number of GHK-Cu?

A: GHK-Cu has a molecular weight of approximately 485.99 g/mol and CAS number 49557-75-7 . The molecular formula is C₁₄H₂₂N₆O₄Cu·C₄H₄O₂ for the acetate salt form .

Q: Do you offer bulk quantities of GHK-Cu for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements for ongoing research programs.

Q: Is GHK-Cu legal to purchase for research in the UK and EU?

A: GHK-Cu is legal to purchase for research purposes when properly labeled and supplied to qualified buyers such as laboratories and research facilities . At eupeptidelap.co.uk, all products are intended for research and laboratory use only and are not for human consumption .

Advance Your Research with GHK-Cu 50mg

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Whether you are exploring collagen synthesis pathways, designing wound healing studies, investigating hair growth mechanisms, or researching anti-inflammatory strategies, our rigorously tested compound provides the quality and consistency your work demands. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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