Epithalon 10mg

€31.99

Technical Specifications

Specification	Detail
Product Name	Epithalon (Ala-Glu-Asp-Gly, AEDG)
Quantity	10mg per vial
Purity	≥97.0% (HPLC verified)
Form	Lyophilized powder, no additives
Appearance	White to off-white lyophilized powder
Molecular Weight	390.35 Da
CAS Number	307297-39-8
Amino Acid Sequence	H-Ala-Glu-Asp-Gly-OH
Synonyms	Epitalon, Epithalone, AlaGluAspGly
Solubility	Sterile 18MΩ-cm H₂O ≥100 μg/ml; Water ≥50 mg/mL
LogP	-2.02
tPSA	225 Å²
Hydrogen Bond Donors	7
Hydrogen Bond Acceptors	10
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	4°C for 2-7 days; below -18°C for long-term with carrier protein
Shelf Life	3 years from manufacture date
Shipping	Ambient temperature with protective packaging
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

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Description

Premium Epithalon (Ala-Glu-Asp-Gly) for Sale | ≥97% Purity | 48-Hour Delivery Across EU & UK

Epithalon (Ala-Glu-Asp-Gly): The Pineal Tetrapeptide at the Forefront of Longevity Research

eupeptidelap.co.uk is proud to present Epithalon 10mg, a premium research-grade synthetic tetrapeptide manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with Epithalon for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in gerontology, telomere biology, and neuroendocrine regulation .

Epithalon (also known as Epitalon, Epithalone, or by its amino acid sequence Ala-Glu-Asp-Gly/AEDG) is a synthetic tetrapeptide developed based on the amino acid composition of Epithalamin, a polypeptide complex naturally occurring in the bovine pineal gland . For many years, the presence of Epithalon in the human body remained unconfirmed, until 2017, when it was detected for the first time in physiological pineal gland extract, confirming its natural origin and biological relevance . This peptide has been extensively studied over the past 25 years using in vitro, in vivo, and in silico methods, demonstrating significant geroprotective and neuroendocrine effects .

The molecular formula of Epithalon is C₁₄H₂₂N₄O₉, with a molecular weight of 390.35 Da, and its amino acid sequence is H-Ala-Glu-Asp-Gly-OH . Unlike the complex natural extract Epithalamin, Epithalon has a precisely defined chemical structure that allows for greater reproducibility in research settings . The results of numerous studies indicate significant geroprotective and neuroendocrine effects of Epithalon, resulting from its antioxidant, neuroprotective, and antimutagenic effects, originating from both specific and nonspecific mechanisms .

For researchers seeking to buy peptide online EU for investigations into telomere biology, cellular senescence, circadian rhythm regulation, or age-related disease models, eupeptidelap.co.uk offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

The Scientific Foundation of Epithalon Research

Discovery and Development

Epithalon was developed based on the amino acid composition of Epithalamin, a pineal polypeptide extract from cattle first described in scientific research in 1973 . The discovery of the bioactivity of this extract and its first research were mainly led by V.K. Khavinson and V.N. Anisimov . Since then, Epithalamin has been widely studied, including in clinical trials, showing a normalizing effect on the basic functions of the human organism and, as a result, establishing it as a geroprotective agent . Epithalon was subsequently synthesized at the St. Petersburg Institute of Bioregulation and Gerontology, offering a defined molecular structure that enables standardized research applications .

Primary Mechanisms of Action

Telomerase Activation and Telomere Maintenance: One of the most significant mechanisms attributed to Epithalon is its ability to influence telomerase activity and telomere dynamics . Telomeres are DNA-protein complexes that cap chromosome ends, protecting genetic material. With each cell division, telomeres shorten; when critically short, cells enter senescence (irreversible growth arrest) . Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism .

Pineal Gland Regulation and Circadian Biology: The pineal gland is central to regulating sleep-wake cycles through melatonin production . Aging is associated with reduced melatonin, impairments in circadian rhythm, and downstream effects on longevity . Epithalon has been shown to stimulate melatonin synthesis and normalize the circadian rhythm of cortisol secretion in senescent female M. mulatta monkeys . Research demonstrates Epithalon’s direct effect on melatonin synthesis in pineal cells, with studies showing statistically important impacts on arylalkyl amine-N-acetyltransferase (AANAT) and cyclic AMP-responsive element-binding protein (pCREB) concentrations, suggesting a more prolonged mechanism of action and significantly greater potency after three hours of experiment .

Antioxidant and Antimutagenic Effects: Epithalon has demonstrated significant antioxidant properties, reducing levels of lipid peroxidation products in aged D. melanogaster tissue homogenates . It decreases the frequency of bone marrow cell chromosomal aberrations in female mice, indicating antimutagenic properties . At the cellular level, Epithalon reduces reactive oxygen species, counteracting age-related oxidative stress that contributes to cellular damage .

Immune Modulation: Epithalon influences immune function through multiple pathways. It has been shown to alter the mRNA levels of interleukin-2 (IL-2) in splenocytes derived from CBA mice . In pineal gland cultures derived from rats, Epithalon decreased the quantity of undifferentiated CD5+ cells and increased the expression of the B-cell marker CD20, suggesting it may enhance the development of lymphocyte precursors into B cells . Some studies suggest improved immune markers (increased activity or counts of T-helper and NK cells) in treated older adults .

Neuroprotective and Neurogenic Effects: Epithalon has demonstrated neuroprotective properties, with intranasal administration shown to increase neuronal activity . It has been confirmed to fully stop the decrease in neprilysin (NEP) and insulin-degrading enzyme (IDE) mRNA synthesis in hypoxia-cultured NB7 cells, revealing Epithalon’s antihypoxic characteristics . Research also demonstrates Epithalon’s ability to modulate neurogenesis through epigenetic mechanisms, affecting how neural proteins are transcribed from DNA to facilitate regrowth and learning capacity that typically decline with age .

Anti-Cancer Properties: Substantial evidence supports Epithalon’s anticancer properties across multiple experimental models. In C3H/He mice, long-term exposure to small doses of Epithalon decreased the number of tumor-bearing mice with malignant tumors and completely prevented the development of metastases, while control mice developed metastases in 3 out of 9 tumor-bearing animals . In transgenic mice carrying the HER-2/neu breast cancer gene, Epithalon decreased the incidence of breast adenocarcinomas and lung metastases, increased the number of mice without breast tumors, and prolonged the lifetime of mice with breast tumors by 1.4-fold compared to controls . In chemically-induced cancer models, Epithalon significantly decreased the number of colon tumors in 1,2-dimethylhydrazine-exposed rats and inhibited tumor development in the jejunum and ileum .

Key Research Applications

Telomere Biology and Cellular Senescence Research

Epithalon serves as a valuable tool for investigating telomere dynamics and cellular aging mechanisms. Several small-scale trials involving elderly participants (typically 60-80 years) report maintenance or elongation of peripheral blood leukocyte telomeres after Epithalon administration for a period of 2–3 years . These studies frequently used subcutaneous Epithalon injections, with reported improvements in certain functional aging indices (e.g., sleep, physical performance) . The ability of Epithalon to modulate telomerase activity in somatic cells provides a research model for studying telomere reactivation and its consequences .

Longevity and Gerontology Research

Multiple studies provide compelling evidence for Epithalon’s effects on longevity across different experimental models. A landmark Russian study administered Epithalon and thymulin to 266 elderly individuals over 6-8 years with annual ten-day peptide treatments, resulting in a 4.1-fold decrease in mortality compared to the placebo group . In animal models, Epithalon treatment led to longer mean and maximum survival rates in senescence-accelerated mice (SAM), particularly noting extended survival in the 10% of last survivors . In outbred Swiss-derived SHR mice, Epithalon increased maximum lifespan by 12.3% compared to controls . These consistent findings across various mammalian models suggest Epithalon may influence fundamental aging mechanisms rather than simply addressing specific pathologies.

Pineal Function and Circadian Rhythm Research

Epithalon’s effects on pineal gland function make it particularly valuable for circadian biology research. Studies indicate Epithalon restores impaired pineal gland function, which naturally atrophies and calcifies with age (a process even more pronounced in neurological diseases like Alzheimer’s and Parkinson’s) . The peptide stimulates melatonin synthesis and normalizes cortisol secretion circadian rhythm in senescent models, addressing key hormonal dysregulations associated with aging . Research in isolated perifused pineal glands from both young and aged rats has helped elucidate the mechanisms underlying these effects .

Cancer Research and Metastasis Studies

Epithalon’s anti-cancer and anti-metastatic properties make it a valuable tool for oncology research. In C3H/He mice with spontaneous tumors, treatment with Epithalon completely prevented metastasis development, while in the control group, metastases were found in 3 out of 9 tumor-bearing mice . This anti-metastatic effect appears to be a significant component of Epithalon’s oncostatic properties and may be related to its ability to inhibit invasive cell behaviors. The peptide shows variable efficacy against different tumor types, with particularly strong effects against hormone-dependent cancers and hematological malignancies . In Swiss-derived SHR mice, while Epithalon did not influence the total incidence of spontaneous tumors, it specifically inhibited leukemia development by 6-fold relative to the control group, suggesting selective efficacy against certain cancer types .

Neuroprotection and Neurodegenerative Disease Research

Epithalon’s neuroprotective properties position it as a candidate for investigating interventions in conditions like Alzheimer’s and Parkinson’s disease. Research demonstrates Epithalon’s ability to fully prevent the decrease in neprilysin and insulin-degrading enzyme mRNA synthesis in hypoxia-cultured cells, revealing antihypoxic characteristics relevant to neurodegenerative disease models . The peptide’s influence on melatonin synthesis and circadian rhythm regulation may also have implications for sleep disorders and age-related cognitive decline.

Immunosenescence and Immune Function Research

Epithalon’s immunomodulatory effects make it relevant for studying age-related immune decline. Studies demonstrate Epithalon’s influence on IL-2 mRNA levels, B-cell marker expression, and lymphocyte precursor differentiation . Longitudinal data show reduced all-cause mortality over 6–12 years for Epithalon-treated elderly cohorts compared to controls, potentially related to improved immune function and reduced infection frequency .

Reproductive Aging Research

Epithalon has demonstrated effects on reproductive senescence in animal models. It delays age-related estrous shutdown in female mice and restores reproductive capacity in older female rats, suggesting effects on reproductive aging . These properties make Epithalon valuable for research into age-related fertility decline and reproductive system aging.

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

eupeptidelap.co.uk sources Epithalon 10mg from certified GMP facilities with rigorous quality control protocols:

HPLC Purity Analysis: ≥97.0% purity verified by reverse-phase high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation (390.35 Da) via LC-HRMS
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Sterile Manufacturing: Lyophilized with no additives; sterile filtered
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations

Chemical and Product Specifications

Specification	Detail
Product Name	Epithalon (Epitalon, Epithalone, Ala-Glu-Asp-Gly)
CAS Number	307297-39-8
Molecular Formula	C₁₄H₂₂N₄O₉
Molecular Weight	390.35 Da
Amino Acid Sequence	H-Ala-Glu-Asp-Gly-OH (AEDG)
Purity	≥97.0% (HPLC verified)
Appearance	Sterile filtered white lyophilized powder
Form	Lyophilized powder with no additives
Solubility	Reconstitute in sterile 18MΩ-cm H₂O at not less than 100 μg/ml ; Water: ≥50 mg/mL ; DMF, DMSO, PBS also soluble
Storage (Lyophilized)	Below -18°C, desiccated; stable at room temperature for 3 weeks ; 3 years at -20°C in powder form
Storage (Reconstituted)	4°C for 2-7 days; below -18°C for long-term with carrier protein (0.1% HSA or BSA)
Shipping	Ambient temperature with protective packaging
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

Stability and Handling Guidelines

Lyophilized Powder Storage: Store lyophilized Epithalon powder below -18°C in a dry, dark environment, protected from light and moisture, and kept desiccated . While the peptide is stable at room temperature for up to 3 weeks, refrigeration or freezing is recommended for extended storage . Powder stored at -20°C maintains stability for up to 3 years .

Reconstitution Protocol:

Allow vial and solvent to reach ambient temperature before opening to prevent condensation
Reconstitute using sterile 18MΩ-cm H₂O at not less than 100 μg/ml, which can then be further diluted to other aqueous solutions
Inject solvent slowly down the inside wall of the vial to minimize foaming
Gently swirl or roll the vial until fully dissolved—do not shake vigorously
Label the vial with the date of reconstitution
Refrigerate immediately at 4°C

Reconstituted Solution Storage: Store reconstituted Epithalon at 4°C for 2-7 days . For long-term storage, aliquot into single-use portions, add a carrier protein (0.1% HSA or BSA), and store below -18°C . Prevent repeated freeze-thaw cycles.

Protection from Light and Moisture:

Store in original packaging protected from light
Keep vials tightly sealed when not in use
Allow refrigerated vials to reach room temperature before opening to prevent condensation

Solubility Information: Epithalon is highly soluble in water (≥50 mg/mL) . For DMSO-based formulations, solubility is 1-3 mg/mL depending on the preparation . For in vivo research applications, various formulation vehicles are available including DMSO/PEG300/Tween 80/saline combinations and corn oil preparations.

Key Benefits

Premium Quality Manufacturing: GMP-certified production, ≥97% HPLC-verified purity
Well-Characterized Tetrapeptide: Extensively studied over 25 years using in vitro, in vivo, and in silico methods
Telomerase Activation: Induces telomerase activity and telomere elongation in somatic cells
Pineal Gland Regulation: Stimulates melatonin synthesis and normalizes cortisol circadian rhythm
Geroprotective Effects: Demonstrates significant lifespan extension in multiple animal models and human studies
Mortality Reduction: 4.1-fold decrease in mortality in elderly human cohorts over 6-8 years
Antioxidant Properties: Reduces lipid peroxidation and chromosomal aberrations
Anti-Cancer Activity: Decreases spontaneous tumor development and completely prevents metastasis
Anti-Metastatic Effects: In C3H/He mice, Epithalon completely prevented metastasis while 33% of controls developed metastases
Neuroprotective Effects: Increases neuronal activity and protects against hypoxia-induced mRNA decreases
Immune Modulation: Alters IL-2 mRNA levels and influences lymphocyte differentiation
Circadian Rhythm Research: Restores impaired pineal function and normalizes neuroendocrine regulation
Reproductive Aging: Delays age-related estrous shutdown in female mice
Antihypoxic Properties: Fully prevents decrease in neprilysin and IDE mRNA under hypoxic conditions
Well-Characterized Safety Profile: Favorable short-term safety in clinical studies with minimal reported adverse effects
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is Epithalon and how does it work?

A: Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide developed based on the amino acid composition of Epithalamin, a natural pineal gland polypeptide complex . It works through multiple mechanisms including telomerase activation, pineal gland regulation, antioxidant effects, and modulation of neuroendocrine function . The peptide has been shown to induce telomerase activity in somatic cells, stimulate melatonin synthesis, and normalize cortisol circadian rhythms .

Q: What is the molecular weight and sequence of Epithalon?

A: Epithalon has a molecular weight of 390.35 Da and the amino acid sequence H-Ala-Glu-Asp-Gly-OH (AEDG) . Its molecular formula is C₁₄H₂₂N₄O₉ .

Q: What purity level can I expect when I buy Epithalon from eupeptidelap.co.uk?

A: All Epithalon 10mg from eupeptidelap.co.uk is tested to ≥97.0% purity by HPLC . Each batch is individually analyzed, and Certificates of Analysis are provided with every order, ensuring you receive material suitable for rigorous research applications.

Q: How should I store Epithalon for long-term stability?

A: Store lyophilized Epithalon powder below -18°C in a dry, dark environment, protected from light and moisture, and kept desiccated . While stable at room temperature for up to 3 weeks, refrigeration or freezing is recommended for extended storage . Powder stored at -20°C maintains stability for up to 3 years .

Q: What is the recommended reconstitution protocol for Epithalon?

A: Reconstitute using sterile 18MΩ-cm H₂O at not less than 100 μg/ml, which can then be further diluted to other aqueous solutions . Inject solvent slowly down the inside wall of the vial to minimize foaming, gently swirl—do not shake. After reconstitution, store at 4°C for 2-7 days . For long-term storage, aliquot into single-use portions, add a carrier protein (0.1% HSA or BSA), and store below -18°C. Prevent repeated freeze-thaw cycles.

Q: What is the solubility of Epithalon in various solvents?

A: Epithalon is highly soluble in water (≥50 mg/mL) . In DMSO, solubility is approximately 1-3 mg/mL depending on the preparation . It is also soluble in DMF and PBS . For in vivo research, various formulation vehicles are available including DMSO/PEG300/Tween 80/saline combinations and corn oil preparations .

Q: What research areas commonly use Epithalon?

A: Epithalon is widely used in telomere biology and cellular senescence research, longevity and gerontology studies, pineal function and circadian rhythm research, cancer research and metastasis studies, neuroprotection and neurodegenerative disease research, immunosenescence and immune function research, and reproductive aging studies .

Q: Does Epithalon have anti-cancer properties?

A: Yes, substantial evidence supports Epithalon’s anticancer properties. In C3H/He mice, Epithalon completely prevented metastasis development while 33% of control animals developed metastases . In transgenic mice carrying the HER-2/neu breast cancer gene, Epithalon decreased breast adenocarcinoma incidence and lung metastases, and prolonged the lifetime of mice with breast tumors by 1.4-fold . It also significantly decreased colon tumors in chemically-induced cancer models .

Q: Do you ship Epithalon to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship Epithalon 10mg to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays. All shipments use protective packaging to maintain compound integrity during transit.

Q: What documentation do you provide with Epithalon orders?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data. Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.

Q: What is the evidence for Epithalon’s effects on longevity?

A: A landmark Russian study administering Epithalon to 266 elderly individuals over 6-8 years resulted in a 4.1-fold decrease in mortality compared to placebo . In animal models, Epithalon increased maximum lifespan by 12.3% in outbred Swiss-derived SHR mice and prolonged the average lifetime of transgenic mice without neoplasms by 34.2% . Senescence-accelerated mice also showed extended mean and maximum survival with Epithalon treatment .

Q: Does Epithalon affect melatonin production?

A: Yes, Epithalon directly influences melatonin synthesis. Studies have shown it stimulates melatonin synthesis and normalizes the circadian rhythm of cortisol secretion in senescent monkeys . Research demonstrates Epithalon’s effect on AANAT and pCREB in pinealocyte culture, underlying peptide regulation of pineal cell activity .

Q: What is the difference between Epithalon and Epithalamin?

A: Epithalamin is a complex polypeptide extract from bovine pineal gland containing multiple bioactive peptides . Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed based on the amino acid composition of Epithalamin . Unlike the natural extract, Epithalon has a precisely defined chemical structure that allows for greater reproducibility in research settings .

Q: Do you offer bulk quantities of Epithalon for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements for ongoing research programs.

Advance Your Research with Epithalon 10mg

eupeptidelap.co.uk is your trusted source for Epithalon 10mg, the premium choice for researchers investigating telomere biology, cellular senescence, neuroendocrine regulation, and age-related disease mechanisms. With over 25 years of preclinical and clinical research supporting its geroprotective and neuroendocrine effects, Epithalon represents one of the most extensively studied peptides in longevity research. ...........................................

Whether you are exploring telomerase activation pathways, designing aging studies, investigating pineal function, or researching anti-cancer mechanisms, our rigorously tested compound provides the quality and consistency your work demands. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Order today and experience the eupeptidelap.co.uk difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.

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