Buprenorphine (Subutex) | Analytical Reference Standard

Are you seeking a verified, high-purity source for Buy Subutex Online for laboratory use? Buprenorphine, widely known by the brand name Subutex, is a semi-synthetic derivative of the thebaine alkaloid. Within the scientific community, it is a primary subject for researchers investigating opioid receptor polypharmacology, the “ceiling effect” on respiratory depression, and the development of high-resolution forensic detection assays.

We provide analytical-grade Buprenorphine Hydrochloride, verified via HPLC and LC-MS/MS to ensure the $\geq$ 98% purity required for rigorous in vitro pharmacological investigations and equipment calibration.

Pharmacological Profile & Mechanism of Action

Buprenorphine is utilized as a sophisticated chemical probe to study the complex modulation of the endogenous opioid system. Researchers utilize this compound to explore:

Partial Mu-Agonism: Investigating its high affinity but low intrinsic activity at the $\mu$ -opioid receptor. This unique profile contributes to its role in opioid use disorder research and its “ceiling effect” on analgesia.
Kappa & Delta Antagonism: Researching its activity as an antagonist at the $\kappa$ -opioid receptor and $\delta$ -opioid receptor, which are linked to mood regulation and stress responses.
ORL-1 Receptor Agonism: Studying its activity at the Nociceptin/Orphanin FQ (ORL-1) receptor, which may influence its analgesic and sedative properties.

Primary Research & Forensic Applications

Buprenorphine is an essential reference material for several advanced scientific domains:

Forensic Toxicology: Serving as a validated reference standard (CAS: 53152-21-9) for identifying and quantifying the substance and its primary metabolite, Norbuprenorphine, in biological matrices.
Metabolic Mapping: Investigating the Cytochrome P450 3A4 mediated N-dealkylation pathways in in vitro hepatic models.
Analytical Method Development: Utilizing high-purity standards to calibrate GC-MS and LC-MS systems for the ultra-sensitive detection of buprenorphine in clinical and forensic samples.

Technical Specifications

Feature	Details
IUPAC Name	(2S)-2-[(5R,6R,7R,14S)-17-(cyclopropylmethyl)-4,5-epoxy-3-hydroxy-6-methoxy-15,16-dihydro-7H-6,14-ethenomorphinan-7-yl]-3,3-dimethylbutan-2-ol
CAS Number	53152-21-9 (HCl) / 52485-79-7 (Base)
Molar Mass	504.10 g/mol (HCl)
Purity Grade	Analytical Reference Grade ( $\geq$ 98%)
Molecular Formula	$C_{29}H_{41}NO_{4} \cdot HCl$

Safety, Regulatory Status, and Procurement

Buprenorphine is a controlled substance and is intended strictly for authorized laboratory research.

Regulatory Compliance: In the US, Buprenorphine is a Schedule III Controlled Substance. In the EU and UK, it is subject to strict narcotics regulations. Procurement requires valid institutional licensing and adherence to international treaty requirements for the handling of opioids.
Handling & PPE: Due to high physiological activity and potential for secondary exposure, the use of Personal Protective Equipment (PPE), including nitrile gloves, eye protection, and a certified fume hood, is mandatory.
Storage: To maintain maximum molecular stability, store at recommended temperatures in airtight, light-protected containers.

Why Source Through Licensed Distribution Channels?

Verified Analytical Integrity: Every batch is independently tested to ensure your research is conducted with materials of known concentration and high purity.
Chain of Custody: Professional logistics ensure tracked, secure shipping, maintaining the regulatory compliance required for institutional and academic facilities.
Technical Documentation: Orders are supported by batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS).

Buy Subutex Online

Advance your neuropharmacological and forensic investigations with certified Buprenorphine standards. Contact our specialized distribution team today to secure high-purity materials for your facility.