Hydroxetamine (HXE) | Analytical Reference Standard

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Are you seeking a verified, high-purity source for Hydroxetamine for laboratory use? Hydroxetamine, also known as 3-HO-2′-oxo-PCE, is a dissociative anesthetic of the arylcyclohexylamine class. It is a structural analog of both MXE (Methoxetamine) and 3-HO-PCP. Within the scientific community, HXE is a primary subject for researchers investigating NMDA receptor antagonism and the development of high-resolution forensic detection assays.

We provide analytical-grade Hydroxetamine Hydrochloride, verified via HPLC and LC-MS/MS to ensure the $\geq$ 98% purity required for rigorous in vitro pharmacological investigations and equipment calibration.

Pharmacological Profile & Mechanism of Action

HXE is utilized as a sophisticated chemical probe to study the impact of 3-hydroxy substitution on arylcyclohexylamine scaffolds. Researchers utilize this compound to explore:

NMDA Receptor Antagonism: Investigating its role as a non-competitive antagonist at the N-Methyl-D-Aspartate (NMDA) receptor site, which modulates excitatory neurotransmission and synaptic plasticity.
Monoaminergic Modulation: Researching HXE’s potential secondary interactions with serotonin and norepinephrine transporters, a characteristic often shared by 3-substituted arylcyclohexylamines.
Structure-Activity Relationship (SAR): Studying how the absence of the 3-methoxy group (found in MXE) and the presence of the 3-hydroxy group (found in HXE) alters binding affinity and metabolic stability.

Primary Research & Forensic Applications

Buy Hydroxetamine (HXE) Online, is an essential reference material for several advanced scientific domains:

Forensic Toxicology: Serving as a validated reference standard (CAS: 2163901-57-5) for identifying and quantifying Novel Psychoactive Substances (NPS) in complex biological matrices like blood, urine, and vitreous humor.
Metabolic Mapping: Investigating the metabolic pathways of HXE, specifically focusing on the O-demethylation similarities it shares with other arylcyclohexylamines.
Analytical Method Development: Utilizing high-purity standards to calibrate GC-MS and high-resolution mass spectrometry (HRMS) systems for clinical screenings.
Neuropharmacology: Exploring the compound’s impact on glutamate signaling and its potential as a tool for studying antidepressant-like effects in animal models.

Technical Specifications

Feature	Details
IUPAC Name	2-(ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one
CAS Number	2163901-57-5 (HCl)
Molar Mass	233.31 g/mol (Base) / 269.77 g/mol (HCl)
Purity Grade	Analytical Reference Grade ( $\geq$ 98%)
Molecular Formula	$C_{14}H_{19}NO_{2} \cdot HCl$

Safety, Regulatory Status, and Procurement

Hydroxetamine is intended strictly for authorized laboratory research and is not for human consumption.

Regulatory Compliance: As an analog of ketamine and MXE, HXE is subject to “analog acts” or specific scheduling in many jurisdictions (e.g., UK, USA, EU). Procurement requires valid institutional licensing and adherence to ECHA and national health regulations.
Handling & PPE: Due to its potential anesthetic and psychoactive properties, the use of Personal Protective Equipment (PPE), including nitrile gloves and eye protection, is mandatory.
Storage: Store in a cool, dry environment in airtight, light-resistant containers to maintain long-term molecular stability.

Why Source Through Licensed Distribution Channels?

Verified Analytical Integrity: Every batch is independently tested to ensure materials meet the rigorous standards required for peer-reviewed research.
Chain of Custody: Professional logistics ensure tracked, secure shipping, maintaining the regulatory compliance required for institutional facilities.
Technical Documentation: Orders supported by batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS).

Buy Hydroxetamine (HXE) Online | Premium Research Chemicals For Laboratory and Research Purposes.

Advance your neuropharmacological and forensic investigations with certified Hydroxetamine standards. Contact our specialized distribution team today to secure high-purity materials for your facility.