Sildenafil (Viagra) | Analytical Reference Standard

Are you seeking a verified, high-purity source for Buy Viagra Online for laboratory use? Sildenafil, widely recognized by the brand name Viagra, is a pyrazolopyrimidinone derivative. Within the scientific community, it is a primary subject for researchers investigating cyclic GMP (cGMP) signaling pathways, the treatment of pulmonary arterial hypertension, and the development of high-resolution forensic detection assays.

We provide analytical-grade Sildenafil Citrate, verified via HPLC and LC-MS/MS to ensure the $\geq$ 98% purity required for rigorous in vitro pharmacological investigations and equipment calibration.

Pharmacological Profile & Mechanism of Action

Sildenafil is utilized as a sophisticated chemical probe to study the modulation of vascular tone and smooth muscle relaxation. Researchers utilize this compound to explore:

PDE5 Inhibition: Investigating its role as a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which prevents the degradation of cGMP in the corpus cavernosum and pulmonary vasculature.
Nitric Oxide Pathway: Studying the synergy between Sildenafil and Nitric Oxide (NO) release, facilitating vasodilation through the activation of protein kinase G.
Secondary Indications: Researching the compound’s efficacy in treating Pulmonary Arterial Hypertension (PAH) and its potential neuroprotective or cardioprotective properties.

Primary Research & Forensic Applications

Sildenafil is an essential reference material for several advanced scientific domains:

Forensic Toxicology: Serving as a validated reference standard (CAS: 171599-83-0) for identifying and quantifying the substance and its primary metabolite, N-desmethylsildenafil, in biological matrices.
Adulteration Screening: Utilizing high-purity standards to detect the illegal addition of Sildenafil or its structural analogs in herbal supplements and over-the-counter products.
Metabolic Mapping: Investigating the CYP3A4 mediated metabolism pathways and potential drug-drug interactions involving nitrate medications.
Vascular Biology: Exploring the effects of PDE5 modulation on endothelial function and systemic hemodynamics.

Technical Specifications

Feature	Details
IUPAC Name	1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
CAS Number	171599-83-0 (Citrate) / 139755-83-2 (Base)
Molar Mass	666.7 g/mol (Citrate)
Purity Grade	Analytical Reference Grade ( $\geq$ 98%)
Molecular Formula	$C_{22}H_{30}N_{6}O_{4}S \cdot C_{6}H_{8}O_{7}$

Safety, Regulatory Status, and Procurement

Sildenafil is intended strictly for authorized laboratory research and is not for human consumption.

Regulatory Compliance: Procurement requires valid institutional credentials. Sildenafil is a prescription-only medication in most jurisdictions and must be handled in accordance with ECHA and national health regulations.
Handling & PPE: Due to its potent vasoactive properties, the use of Personal Protective Equipment (PPE), including nitrile gloves and eye protection, is mandatory during handling.
Storage: Store in a cool, dry environment in airtight containers to maintain chemical integrity and prevent degradation.

Why Source Through Licensed Distribution Channels?

Verified Analytical Integrity: Every batch is independently tested to ensure materials meet the rigorous standards required for peer-reviewed research.
Chain of Custody: Professional logistics ensure tracked, secure shipping, maintaining the regulatory compliance required for academic and corporate facilities.
Technical Documentation: Orders supported by batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS).

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Advance your cardiovascular and pharmacological investigations with certified Sildenafil standards. Contact our specialized distribution team today to secure high-purity materials for your facility.